In such depression, gifted children typically try to find some sense of meaning, some anchor point which they can grasp to pull themselves out of the mire of “unfairness.” Often, though, the more they try to pull themselves out, the more they become acutely aware that their life is finite and brief, that they are alone and are only one very small organism in a quite large world, and that there is a frightening freedom regarding how one chooses to live one’s life. It is at this point that they question life’s meaning and ask, “Is this all there is to life? Is there not ultimate meaning? Does life only have meaning if I give it meaning? I am a small, insignificant organism who is alone in an absurd, arbitrary and capricious world where my life can have little impact, and then I die. Is this all there is?”

From Existential depression in gifted individuals via HackerNews.